 Research
 Open Access
Multiple imputation using chained equations for missing data in TIMSS: a case study
 Donia Smaali Bouhlila^{1}Email author and
 Fethi Sellaouti^{1}
https://doi.org/10.1186/2196073914
© Bouhlila and Sellaouti; licensee Springer. 2013
 Received: 28 August 2013
 Accepted: 3 September 2013
 Published: 16 September 2013
Abstract
In this paper, we document a study that involved applying a multiple imputation technique with chained equations to data drawn from the 2007 iteration of the TIMSS database. More precisely, we imputed missing variables contained in the student background datafile for Tunisia (one of the TIMSS 2007 participating countries), by using Van Buuren, Boshuizen, and Knook’s (SM 18:681694,1999) chained equations approach. We imputed the data in a way that was congenial with the analysis model. We also carried out different diagnostics in order to determine if the imputations were reasonable. Our analysis of multiply imputed data confirmed that the power of multiple imputation lies in obtaining smaller standard errors and narrower confidence intervals in addition to allowing one to work with the entire dataset.
Keywords
 Multiple Imputation
 Complete Case Analysis
 Imputation Model
 Impute Dataset
 Posterior Predictive Distribution
Background
Missing data are a part of almost all research. Scrutiny of data from the iterations of TIMSS (Trends in International Mathematics and Science Study) makes clear that the survey participants, whether students, teachers, or school principals, fail to complete all of the items of their respective questionnaires. Because TIMSS data offer a rich array of information about the major factors thought to predict student achievement in mathematics and science, the incomplete cases mean not only a loss of power of the analyzed data but also the potential to bias the estimates of interest (Little, 1992; Little & Rubin, 2002).
Our aim in this paper is to apply the multiple imputation technique introduced by Rubin in the early 1970s (see Rubin, 1987) to a TIMSS dataset and thereby explore its possibility as a solution to the problem of survey nonresponse. We begin by examining the theoretical underpinnings of multiple imputation and then briefly describe traditional imputation approaches. Next, we use Van Buuren, Boshuizen, and Knook’s (1999) multiple imputation by chained equations approach to provide an illustration of imputing student background data missing from the TIMSS 2007 datafile for Tunisia.
Multiple imputation: a review of the literature
Among the traditional methods developed to enable investigators to make statistical inferences when data are incomplete are listwise deletion or complete case analysis, pairwise deletion, mean substitution, regression imputation, and inclusion of an indicator variable.^{a} Over the last two decades, investigators have used these methods, despite their drawbacks, extensively in their empirical research. The drawbacks include further loss of data, biasing the sample statistics, and reducing the variance of the variable in question (Acock, 2005; Little & Rubin, 2002; Peugh & Enders, 2004; Rubin, 1987).
More statistically principled methods for handling missing data also exist. They include the maximum likelihood estimation via the expectation maximization algorithm (EM) (Dempster, Laird, & Rubin 1977) and multiple imputation (Little & Rubin, 2002; Rubin, 1978 1987 1996; Schafer & Graham 2002). These methods produce estimates that are superior to those of the older methods, but for many researchers, multiple imputation is the general solution to missingdata problems in statistics (Rubin, 1996; Schafer, 1997). Certainly, multiple imputation is an innovative approach over the traditional ones. On the one hand, researchers in many fields can use it. On the other hand, because its implementation is becoming easier (thanks to the existence of statistical software packages), researchers are tempted to use it despite the problems associated with it.^{b}
What is multiple imputation?
Before explaining what multiple imputation is, we consider it useful to study the mechanisms and patterns associated with missing data.
Exploring missingdata mechanisms
The missingdata mechanism has three classifications (Rubin, 1976): missing at random (MAR), missing completely at random (MCAR), and missing not at random (MNAR). Data are said to be missing at random (MAR) if other variables in the dataset can be used to predict missingness on a given variable. For example, in surveys, men may be more likely than women to refuse to answer some questions. Here, data will be missing completely at random (MCAR) because the process that causes missingness does not depend on the values of variables in the dataset subject to analysis (Little, 1988; Rubin, 1976; Zhang, 2003).
MCAR is a fairly strong assumption, and tends to be relatively rare. For instance, in the context of survey data, MCAR data might occur when a respondent simply skips an item or a question, perhaps because of neglecting to turn the page of a questionnaire booklet. MAR is a less restrictive assumption than MCAR. Finally, data are said to be missing not at random (i.e., MNAR, also called nonignorable missing data) if the value of the unobserved variable itself predicts missingness. A classic example of this is income. Individuals with very high incomes generally refuse to answer questions about their earnings. This is not the case for individuals with more modest incomes.^{c}
Careful consideration of the missingdata mechanism is important because different types of missing data require different treatments (Allison, 2000; Schafer, 2003). When data are MCAR, the complete cases analysis will not result in biased parameter estimates. The only cost is a reduction in the sample size and the statistical power of the analysis because MCAR leads to larger standard errors. In contrast, analyzing only complete cases for data that are either MAR or MNAR can lead to biased parameter estimates. Because multiple imputation generally assumes that the data are, at the least, MAR, this approach can also be used on data that are MCAR (Marchenko & Eddings, 2011).
Exploring missingdata patterns
Monotone imputation requires a specific order of the prediction equations. X_{1} is imputed using all of the complete variables as predictors, and X_{2} is then imputed using the observed and imputed values of X_{1} and the other predictor variables. Thus, with this process, the previously imputed variables are added sequentially to the prediction equations of the other imputation variables.^{d}
Overview of multiple imputation
Multiple imputation is a statistical technique for handling incomplete data and for delivering an analysis that makes use of all possible information (Rubin, 1977 1978). It was derived using the Bayesian paradigm (Rubin 1987 1996). Multiple imputations are repeated random draws from the predictive distribution of the missing values. More precisely, multiple imputations are drawn from a posterior predictive distribution of the missing data conditional on the observed data.
When seeking a Bayesian imputation model, we need to take all sources of variability and uncertainty in the imputed values into account in order to yield statistically valid inferences (Rubin, 1987). The process of substituting the predicted values for the missing ones is performed M times (M > 1). (We discuss choice of imputation models and the number of imputations later in this paper.)
Imputing the missing data leads to the database, called the “imputed database”, appearing to be complete, and allows researchers to apply completedatabased methods on each of the M imputed datasets. The parameter estimates, usually known as the regression coefficients, are averaged using rules established by Rubin (1987) to produce a single set of results (see the Appendix to this paper). Multiple imputation thus requires the building of an imputation model in which predictor variables have to be specified. For discussions of the theoretical and statistical foundations of multiple imputation, see Nielsen (2003), Rubin (1987), and Zhang (2003).
Building an imputation model
In order to implement multiple imputation in practice, we first need to specify the predictor variables. Having done that, we can then construct a predictive model.
Specification of the predictor variables
The first task that needs to be accomplished when carrying out multiple imputation is selection of the predictor variables. We discuss several approaches to determining which variables to include.
Meng (1994), Rubin (1996), Taylor et al. (2002), and White, Royston, and Wood (2011) advocate including all variables associated with the probability of missingness, along with the variables contained in the dataset. From a practical perspective, deciding which variables to include can be accomplished by establishing the correlations between each variable to be imputed and the predictors. If the magnitude of a correlation exceeds a certain level, then the applicable variable is included (Van Buuren et al., 1999). Allison (2002), Moons, Donders, Stijnen, and Harrell (2006), and White et al. (2011) all highlight the need to include the dependent variable of the analysis model in the imputation model.
According to several investigators, among them Enders, Dietz, Montague, and Dixon (2006), Graham (2009), and Jolani, Van Buuren, and Frank (2011), the imputation model should be more general than the analysis model in order to capture more associations between the variables. Also, in situations where there are too many variables, Graham (2009) recommends using principal component analysis in order to detect the variables that have high correlations with the dependent variable.
In the same spirit, and in order to have a rich imputation model compatible with the analysis model, Stuart, Azur, Frangakis, and Leaf (2009) argue for the necessity of including in the regression models those variables that lead to some minimum additional Rsquared. Another alternative is to use the variables that will be used in the analysis model in the imputation model (Schafer, 1997, Raghunathan et al., 2001). However, as Raghunathan and his colleagues (2001) have shown, the inclusion of more and more variables leads to the standard errors of the estimates for the analysis model becoming smaller and smaller.
Specification of the imputation model^{c}
The next step in multiple imputation is specification of the imputation model. Two distinct approaches are used—the multivariate normal model and the chained equations approach.
Imputation using the multivariate normal model
The multivariate normal model was introduced by Rubin (1987; see also Little & Rubin 2002). This approach involves drawing from a multivariate normal distribution of all the variables in the imputation model, and it assumes that the variables are continuous and normally distributed. However, many datasets, especially those in international largescale assessment databases, contain several different types of variable—categorical, binary, and skewed continuous. As such, the inclusion of nonnormally distributed variables in an imputation model that assumes normality may introduce bias. A pragmatic approach here is to transform these variables in order to obtain approximate normality (Sterne et al., 2009; White et al., 2011).
Schafer (2001, p. 7) discusses several ways to manage nonnormally distributed variables. For instance, he explains that nominal variables can be modeled in a way to approximate normality, and the continuous imputed values can be rounded off to the required category. Skewed continuous variables can be transformed by standard functions such as the logarithm, the square root, or the reciprocal square root, and after imputation transformed back to the original scale. Other variables with problematic distributions can be transformed by a method based on the empirical cumulative distribution function.
Shafer (2001) used this imputation model to impute the NHANES III dataset after modeling nonnormally distributed variables. Peugh and Enders (2004) demonstrated the use of multiple imputation using the multivariate normal model in the context of the Longitudinal Study of American Youth. Enders et al. (2006) also used this approach to impute missing data in the Longitudinal Study of Adolescents at Risk for the Development of Emotional or Behavioral Disorders. Schafer’s (1999b) NORM program was used to conduct all of these illustrative analyses.^{e}
One drawback of imputing variables by assuming normality is that the distribution of the imputed values may not resemble that of the observed values (White et al., 2011). Although this approach has stronger theoretical underpinnings and some better statistical properties, the chained equations approach works well in practice (Raghunathan et al., 2001; Van Buuren et al., 1999; Van Buuren, Brand, Groothuis–Oudshoorn, & Rubin, 2006).^{f}
Imputation using the chained equations approach^{g}
This approach is sometimes referred to as ICE or MICE (i.e., multiple imputation by chained equations). It is also known as the fully conditional specification and sequential regression multivariate imputation (White et al., 2011). MICE is a practical approach for imputing missing datasets based on a set of imputation models, given that there is one model for each variable with missing values. MICE has been described in the context of medical research conducted by Royston and White (2011), Van Buuren et al. (1999), and White et al. (2011), and it is seen as a suitable approach for imputing incomplete large, national, public datasets. Work conducted by Oudshoorn, Van Buuren, and Van Rijckevorsel (1999) provides an illustration of this approach. They used MICE to obtain a complete version of the Dutch National Services and Amenities Utilization Survey of 1995 (AVO95). The MICE procedure requires development of the MICE algorithm, a description of which follows.
Because the ICE approach involves a series of univariate models rather than a single large model, the MICE approach imputes data on a variable by variable basis by specifying an imputation model per variable. Suppose we have a set of variables X_{1}……X_{k}. Of this set of variables, some or all have missing values. If X_{1} has missing values, it will be regressed on the other variables X_{2} to X_{k}. The estimation is thus restricted to individuals with observed X_{1}. The missing values in X_{1} are then replaced by the predictive values, which are simulated draws from the posterior predictive distribution of X_{1}. The following variable with missing values, X_{2}, is regressed on all the other variables X_{1}, X_{3} to X_{k}. Estimation is thus restricted to individuals with observed X_{2} and uses the imputed values of X_{1}. Here again, the missing values in X_{2} are replaced by simulated draws from the posterior predictive distribution of X_{2}.
This process is repeated for all the other variables in turn for n cycles in order to stabilize the results and to produce single imputed datasets. Royston and White (2011) and Van Buuren et al. (1999) have all suggested that more than 10 cycles are needed for the convergence of the sampling distribution of imputed values, whereas the entire procedure is repeated independently M times, yielding M imputed datasets.
Selecting the number of imputations
It is important to know the number of imputations needed for a good statistical inference. Multiple imputation theorists suggest that small values of M, on the order of three to five imputations, yield excellent results (Rubin, 1987; Schafer & Olsen, 1998). Schafer (1999a) suggests that no more than 10 imputations are usually required. Graham, Olchowski, and Gilreath (2007) recommend that researchers using multiple imputation should perform many more imputations than previously considered sufficient. They reached this conclusion after using a Monte Carlo simulation to test multipleimputation models across several scenarios in which the fraction of missing information^{h} for the parameter being estimated and M were varied.
White et al. (2011) offer another argument in favor of increasing M. Their approach is based on calculating the Monte Carlo error of the results, with the latter defined as the standard deviation across repeated runs of the same imputation procedure with the same data. White and his colleagues showed, using UK700 data,^{i} that Monte Carlo error tends to zero as M increases. The three investigators also advanced a rule of thumb, although they qualified it as not universally appropriate, which states that M should be at least equal to the percentage of incomplete cases in the dataset. If, for example, 70% of cases have complete data, this rule would suggest M = 30.
Imputation models for different types of variables
Imputation models for different types of variables
Type of variable  The model used for imputation 

Continuous variable  Linear regression 
Binary variable  Logistic regression 
Ordinal variable  Ordinal logistic regression 
Nominal variable  Multinomial logistic regression 
Advantages of MICE and comparison of it with the multivariate normal model (MVN)
Despite lacking a theoretical rationale and despite the difficulties encountered when specifying the different imputation models, MICE has several practical advantages (Marchenko, 2011; Van Buuren et al., 2006; Van Buuren & Oudshoorn, 2011; White et al., 2011). The particularly interesting feature of MICE is its flexibility: each variable can be modeled by using a model tailored to its distribution. In addition, MICE can manage imputation of variables defined only on a subset of the data (e.g., pregnant women). MICE can also incorporate variables that are functions of other variables, and it does not require monotone missingdata patterns.
Brief mention of a number of comparisons between MICE and MVN is relevant here (see, in particular, Lee & Carlin, 2010; Marchenko, 2011; Van Buuren, 2007). To begin with, the multivariate normal model has theoretical underpinnings whereas MICE does not. Secondly, MICE imputes data on a variable by variable basis, but MVN uses a joint modeling approach based on a multivariate normal distribution (Schafer, 1997). MICE can also handle different types of variables while the variables imputed under MVN need to be normally distributed or transformed in order to approximate normality (Schafer, 1997). Finally, MICE can include restrictions within a subset of the data, whereas MVN imputation cannot.
Methods
Implementing MICE in the TIMSS datafile for students’ background: a case study
Since their launch in the 1960s by the International Association for the Evaluation of Educational Achievement (IEA), international largescale assessments such as the Trends in Mathematics and Science Study (TIMSS) and the Progress in International Reading Literacy Study (PIRLS) have become increasingly attractive to countries wanting to assess their students’ achievement in mathematics, science, and reading literacy. IEA studies focus on student achievement and the factors related to it. They provide highquality data for evidencebased educational policy and reform.
TIMSS was first conducted in 1994/1995, in 45 countries, at five grade levels (3, 4, 7, and 8, and the final year of secondary school). The second assessment, conducted in 1999, involved 38 countries and surveyed only one grade, Grade 8. The third iteration, in 2003, assessed students in Grades 4 and 8 in 50 countries. Fiftynine countries participated in the fourth survey, in 2007. The students tested this time round were fourth and eighth graders. Just over 60 countries took part in the fifth and most recent TIMSS survey, conducted in 2011 and again surveying fourth and eighth graders. A number of these countries today have at hand data spanning over two decades, that is, from 1995 to 2011. The next TIMSS survey is scheduled for 2015.^{j}
The central aim of TIMSS is to assess students’ achievements in mathematics and science. Another equally important purpose is to produce data that allow investigators to explore and identify factors relating to student learning, such as students’ home backgrounds, as well as other factors arising out of policy changes relating to, for example, curricular emphases, allocation of resources, and instructional practices. These dual purposes are accomplished by administering questionnaires to participating students, their mathematics and science teachers, and the principals of the sampled schools.
The TIMSS assessments use a twostage, clustered sampling design. During Stage 1, school selection is based on a probability proportional to size sampling approach, whereby there is a higher probability of choosing larger schools. The second stage consists of randomly choosing one or two intact classes at Grade 8 level. All students in the selected classes are then assessed, except for students excluded for specified reasons (e.g., intellectual disability) and students absent on the day of assessment. TIMSS also employs school stratification in order to improve the efficiency of the sample design. Both explicit and implicit stratifications are used. However, even in the absence of stratification, the TIMSS samples represent, on average, the different groups found in the wider population (Olson, Martin, & Mullis, 2007, p. 84).
TIMSS researchers use sampling weights to accommodate the fact that the probabilities associated with selecting some units, such as schools, teachers, and students, will differ. It is therefore necessary to consider the purpose of analysis when choosing sampling weights (Rutkowski, Gonzalez, Joncas, & Von Davier, 2010; Schafer, 2001). The inclusion of weights for each individual imputation makes it easier to ensure that the imputation model is appropriate (Rubin, 1996). Our advice regarding imputation of missing data is to use the total student weight when imputing missing values in the student datafile, to use the weight for mathematics/science teacher data when imputing missing values in the mathematics/science teacher file, and to use school weight when imputing nonresponse in the school datafile.
As is the case with data obtained from any other survey, the TIMSS database has missing values. According to Rubin (1987), survey nonresponse includes all the situations in which missing data arise from processing information provided by individuals and the failure of individuals to provide information. “Omitted”, “not administered”, and “don’t know responses” are all considered to be missing values and hence in need of imputation.

Omitted responses: These occur when a student, teacher, or school principal skips a question. Invalid answers in the background questionnaires, such as when the respondent selects two or more response options in a categorical variable, are considered to be omitted and thus missing (Foy & Olson, 2007).

Not administered: The not administered code is used in the TIMSS background questionnaire datafiles when a respondent fails to complete a questionnaire or when a question is not administered because of, for example, having been left out, misprinted, removed from the questionnaire, considered not applicable in some countries,^{k} mistranslated, or deemed not internationally comparable (Foy & Olson, 2007).

Don’t know responses: As Little and Rubin (2002) point out, deciding what to do with individuals who respond with “don’t know” is especially challenging. The don’t know response occurs in questions that, for example, ask students about the highest education level of either parent or about the level of education they themselves expect to complete. In order to consider this subpopulation as part of the population under study, we need to tag the don’t know response as missing and therefore requiring imputation.
Types of variables in TIMSS
TIMSS datafiles contain different variable types: continuous, binary, nominal, and ordinal. Continuous variables are those that have an infinite number of possible values, such as age, plausible values in mathematics and in science, minutes spent teaching mathematics per week to a class, and total school enrollment. Binary variables are nominal variables that have two categories, for example, gender, whether or not students were born in the participating country, and possessions at home, such as a calculator.
Nominal variables are those that have more than two categories, such as whether or not the students’ parents were born in the participating country. Finally, ordinal variables, although similar to nominal variables, differ from the latter because the variables are clearly ordered. Examples of ordinal variables include the highest level of education attained by either parent and the amount of time the student spends watching television or video within a specified time period (e.g., weekly). Rating scales is another category of variables that can be considered ordinal. They include the customary fouror fivepoint Likert scale variables of, for example, strongly disagree, disagree, agree, or strongly agree (with a statement or proposition).
Illustrative analysis
So far we have mainly discussed the approaches used to generate multiply imputed datasets. We have also addressed how MICE could potentially be used in relation to TIMSS background files. In this section, we focus on implementing MICE to missing values of variables contained in the files encompassing background data from the students who participated in TIMSS in Tunisia.^{l} We begin by defining our analysis model. We then use all the variables of the analysis model in the imputation model, and follow this by assessing the missing data in order to determine their pattern and the “mechanism” producing that pattern. We also discuss the different diagnostics we used to determine whether the imputations were reasonable or whether the procedure needed to be modified. Finally, we present our analysis of the multiply imputed data.
The analysis model
We decided to apply our MICE approach to a study examining the relationship between mathematics performance and science performance of the Grade 8 Tunisian students as well as their socioeconomic status and their respective schools’ resources. Since the Coleman report of 1966 (Coleman et al., 1966), an extensive body of literature has built up that explores and identifies the factors associated with students’ achievement in developing and developed countries.
Description of the different variables
Variable  Type of variable  Description 

Age  Continuous  
Number of books (Books)  Ordinal  Five categories: 
1 Less than one shelf  
2 One shelf  
3 One bookcase  
4 Two bookcases  
5 Three or more bookcases  
Possessing calculator (Calculator)  Binary  Two categories: 
1 Yes  
0 Otherwise  
Possessing computer (Computer)  Binary  Two categories: 
1 Yes  
0 Otherwise  
Possessing study desk (Desk)  Binary  Two categories: 
1 Yes  
0 Otherwise  
Possessing a dictionary (Dictionary)  Binary  Two categories: 
1 Yes  
0 Otherwise  
Possessing internet connection (Internet_connection)  Binary  2 Two categories: 
1 Yes  
0 Otherwise  
Parents’ highest education level (Parents’_highest_ed_level)  Ordinal  Five categories: 
1 University degree  
2 Completed postsecondary but not university  
3 Completed uppersecondary education  
4 Completed lowersecondary education  
5 Less than lowersecondary education  
Parents born in country (Parents_born_country)  Nominal  Three categories: 
1 Both parents born in country  
2 Only one parent born in country  
3 Neither parent born in country  
Gender of student (Female)  Binary  Two categories: 
1 Female  
0 Male  
Spend time work on paid jobs (Work_paid_job)  Ordinal  Five categories: 
1 No time  
2 Less than one hour  
3 One to two hours  
4 More than two hours but less than four/  
5 Four or more hours  
Index of availability of mathematics resources (Index_math_ress)  Ordinal  Three categories: 
1 High  
2 Medium  
3 Low  
First plausible value in mathematics (BSMMAT01)  Continuous  
First plausible value in science (BSSSCI01)  Continuous 
Assessing missing data
This step can be accomplished by examining the pattern of missing data as well as exploring the missingdata mechanism. Scrutiny of our data revealed an arbitrary missing pattern, as can be seen in the Appendix (Figure 9) to this paper. Sample statistics indicated that only 76% of observations were complete; the remaining 24% of the data thus contained missing values. The output of the misstable nested presented immediately below clearly shows that the missing values of the different variables were not nested because 10 statements describe the missing value pattern, thereby confirming the arbitrary nature of the missing data pattern (see Misstable nested).
Misstable nested
 1.
Index_math_ress (23)
 2.
Calculator (70)
 3.
Parents_born_country (77)
 4.
Desk (78)
 5.
Dictionary (84)
 6.
Books (109)
 7.
Internet_connection (172)
 8.
Work_paid_job (180)
 9.
Computer (240)
 10.
Parents_highest_ed_level (364)
It is pertinent to note at this point that imputation using chained equations does not require the variables to be imputed in a specific order. The prediction models do not follow a specific order because, by default, the software imputes variables from the most observed to the least observed.
Having determined the pattern of missingness, we next needed to determine the mechanism driving it. The reason for this step relates to the fact that multiple imputation relies on certain assumptions. One assumption is that the data are MAR. However, the missingness at random assumption is not testable. Nevertheless, we can test the assumption of MCAR^{m} data against MAR data (Marchenko & Eddings, 2011a) by, for example, creating a new dummy variable for each existing variable, which takes the value of 1 if a given observation is missing that variable and of 0 if it is not.
The next step is to run a logistic regression analysis, with the missing data dummy as the dependent variable, over the number of completely observed variables. If the observed variables predict missingness, then the data are MAR rather than MCAR. Furthermore, if there are no strong associations between missingness and the observed values, then the data are MCAR rather than MAR (Marchenko & Eddings, 2011). Our data showed no strong associations between missingness and the observed values, so we assumed that the data were MCAR.^{n}
Multiple imputation diagnostics
Imputation techniques require some diagnostics to help determine whether or not the imputations are reasonable. Recent research by a number of investigators has led to the development of important diagnostics that can be utilized before and after the imputation process (Abayomi, Gelman, & Levy, 2008; Carpenter & Kenward, 2008; Graham, 2009; Marchenko & Eddings, 2011; Raghunathan & Bondarenko, 2007; Stuart et al., 2009; Su, Gelman, Hill, & Yajima, White et al., 2011;2011; Van Buuren & Oudshoorn, 2011).
Testing individual models before imputing
 1.
Checking for convergence: The imputation model must run successfully. Sometimes, complex models such as mlogit fail to converge if the number of categorical variables used is large. The reason why is because the large number can lead to small cell sizes. Pinning down the cause of the problem requires dropping some variables and then added them in, in small groups, until the model runs successfully. Although this method is time consuming, it does result in a workable model. Another alternative is to study the correlations between the nominal variable to be imputed and the predictors, and to choose only those that correlate significantly with the variable in question.
 2.
Handling problems of perfect prediction: Checking the model is a crucial step in the process of detecting perfect prediction. Perfect prediction occurs in regression models for categorical outcomes. Such models include logistic, ordered logistic, and multinomial logistic. Perfect prediction occurs whenever the outcome of any predictor variable within a category is always 0 (or always 1). It usually leads to infinite coefficients with infinite standard errors, and it often causes instability during estimation.
 3.
Adding interaction terms: Sometimes, imputing on subsamples is required for two reasons. The first is to ensure we have at hand the correct functional form of the imputation model, and the second is to preserve higherorder dependencies (Collins, Schafer, & Kam, 2001; Rubin, 1996; Schafer, 2001). For instance, we can investigate various interaction effects with respect to gender, race, income, age, and location (i.e., urban/rural). Thus, one way to check for misspecification is to add these interaction terms to the models in order to determine if they are important (Graham, 2009). However, we cannot include a large number of interactions in the imputation models because of computational limitations (Stuart et al., 2009). Also, in “clustered data”, the members of the same cluster can share characteristics. In this situation, we can include the cluster variable (either the strata or the primary sampling units) in the imputation model as an indicator variable (Graham, 2009).
To ensure that each of our imputation models were appropriate, we thoroughly checked them by using the total student weight to weigh each observation in each model. Our conditional models were therefore as follows (See the conditional models below):
Imputation process and convergence check
Results
In this section, we focus on our analysis of the imputed datasets. We used standard statistical procedures for this work. We began by using the survey regression technique to compute the estimation on the complete data. We then used this technique to compute the five imputed datasets. After that, we performed 30 imputations and reanalyzed the estimation results, all of which appear in the Appendix (Figures 11, 12, 13, 14, 15, 16 and 17) to this paper.
As we mentioned earlier, our goal was to study the impact of SES variables and school resources on students’ performance in mathematics and science. Although our analysis was conducted over the first plausible values in mathematics and the first plausible value in science, we report here only the results of the first plausible value in mathematics because the difference between the two results was minor.^{q} The listwise deletion of the original data is reported in Figure 11 in the Appendix.
We next generated five imputed datasets (Figure 12 in the Appendix) running the analyses separately on each dataset, and combining, by using Rubin’s (1987) rules, the parameter estimates and standard errors into a single inference.^{r} The resulting estimates accounted for both within and betweenimputation uncertainty, reflecting the fact that the imputed values were not observed values.
On looking at Figure 12 we observe first that the multiple imputation estimates are quite similar to those obtained from the complete case analysis. However, after imputation, we can see that the standard errors are smaller and the confidence intervals narrower. Three statistics require interpretation at this point. They are the average relative variance increase (RVI), the largest fraction of missing information (FMI), and the degrees of freedom (DF).^{s}
The average relative variance increase (RVI) due to nonresponse is small: 0.0407. It indicates the increase in variance of the estimates because of the missing values: the closer the number is to zero, the less effect missing data have on the variance of the estimate. The largest fraction of missing information (FMI), also called the rate of missing information (Graham et al., 2007; Schafer, 2001; Schafer & Olsen, 1998), reports the largest of all the FMI on coefficient estimates due to missingness. This statistic is particularly relevant because it lets us know whether or not the standard errors are affected by the variability of the imputed values across (in our case) the five datasets (Schafer, 2001).
Number and percentage of missing data
Variable  Missing  Total  Missing (total %) 

Books  109  4,080  2.67 
Calculator  70  4,080  1.71 
Computer  240  4,080  5.88 
Desk  78  4,080  1.91 
Dictionary  84  4,080  2.05 
Internet_connection  172  4,080  4.21 
Parents’_highest_ed_level  364  4,080  8.92 
Parents_born_country  77  4,080  1.88 
Work_paid_job  180  4,080  4.41 
Index_math_ress  23  4,080  0.56 
Age  0  4,080  0.00 
Female  0  4,080  0.00 
First plausible value in mathematics (BSMMAT01)  0  4,080  0.00 
First plausible value in science (BSSSCI01)  0  4,080  0.00 
We can also use FMI to judge if the number of imputations is sufficient or not for analysis (White et al., 2011). A rule of thumb with respect to FMI is that the number of imputations M > = 100*FMI. In our case, FMI was 0.1565 and the number of imputations was five. Therefore, according to this rule, we need to increase M.
As shown in Figure 13 degrees of freedom (DF) could be obtained for each coefficient. Averaging out at 131.99, the degrees of freedom are large. The reason is that multiple imputation degrees of freedom not only depend on the number of imputations but also inversely relate to the RVI. Also, and again as evident in Figure 13 the degrees of freedom were obtained under a small sampleassumption adjustment, which was determined by the type of reference distribution used for inference. The model F test assumes that the fractions of missing information of all coefficients are equal (equal FMI) and thus rejects the hypothesis that all coefficients are equal to zero.
Finally, we used the Taylor linearization variance estimation method to compute the variance estimates in each completed data analysis. Here we can see, in Figure 13 that the smallest degrees of freedom correspond to the coefficient for parents’_highest_ed_level (2, 3, 4, and 5) (parents’ highest attained level of education) because it contains the highest share of missing values. The largest degrees of freedom can be observed for the coefficient age, indicating that the loss of information due to nonresponse is the smallest for this coefficient. Figure 13 also displays, as a percentage, the increase in standard errors of the parameters due to missingness. Apparent is the increase from 0.03% (though negligible) to 8.20% in the standard errors for the coefficients.
In order to provide information about the variance specific to each parameter, Figure 14 displays the withinimputation variance and the betweenimputation variance (see Rubin’s rules in the Appendix). It also sets out RVI, FMI specific to each parameter, and the relative efficiency of the overall imputation, which can be also used as an approximation when endeavoring to determine the number of imputations (Graham et al., 2007; White et al., 2011).
What we notice first in Figure 14 is that the betweenimputation variability is very small relative to the withinimputation variability. The second aspect of interest is that age and female have the smallest withinimputation and betweenimputation variances. As expected, parents’ highest level of education has the highest RVI and FMI. The reported relative efficiencies are high for all the coefficient estimates, suggesting the need to increase the number of imputations. These estimates are useful in indicating whether or not we should increase the number of imputations. However, we could also compute the Monte Carlo errors (MCE) of the estimates in order to help us reach this determination (White et al., 2011).
 1.
The Monte Carlo error of a coefficient should be less than or equal to 10% of its standard error.
 2.
The Monte Carlo error of a coefficient’s Tstatistic should be less than or equal to 0.1.
 3.
The Monte Carlo error of a coefficient’s Pvalue should be less than or equal to 0.01 if the true Pvalue is 0.05, or 0.02 if the true Pvalue is 0.1.
A look at the estimates in Figure 15 makes clear that these guidelines were not met for the following variables: computer, internetconnection, work on paid job (2, 3, and 4), and parents’_highest_ed_level (2, 3, 4 and 5). Increasing the number of imputations therefore seemed necessary.
In our example, 24% of the data were missing. Given the recommendation by White et al. (2011) that the number of imputations should be at least equal to the percentage of incomplete cases, we decided to perform 30 imputations. Figure 16 displays the results of this stage of our analysis.^{t} We can see that the Monte Carlo errors now satisfy the guidelines. In addition, the estimates are quite similar to those obtained from the complete case analysis: the standard errors are smaller (Figure 17), and the confidence intervals are narrower. Increasing the number of imputations has thus led to more precision in computing the pvalues, standard errors, confidence intervals, and fractions of missing information (Bodner, 2008).
Discussion
In this paper, we have described and evaluated the MICE procedure that can be used to impute missing values of different categories of variables. Although this approach lacks formal theoretical justification, it has the strong advantage of flexibility. Presumably, MICE can be used for TIMSS missingdata problems, given that most variables with missing data in the TIMSS background datafiles are not normally distributed.
The difficulty in implementing MICE lies in the choice of predictor variables and interaction terms. To avoid bias and gain precision, researchers recommend that the imputation models contain—at the least—every variable included in the analysis model. However, the inclusion of interaction terms is a tedious process. A way to determine an interaction is to think of one of the variables as a grouping variable, such as gender (Graham, 2009), and then to carry out separate imputations for females and males.
Another matter associated with implementation of MICE is the issue of weights. TIMSS datafiles contain different kinds of weights, so before imputing the missing data we need to ask ourselves this question: Which weight should I use? As Rutkowski et al. (2010) point out, choice of weights depends on the purpose of the analysis and the research question. The inclusion of weights for each individual imputation makes it easier to ensure that the imputation model is appropriate. The appropriate weight to use when imputing students’ missing data is total student weight. The weight to use when imputing missing values in the mathematics teacher file is the weight for the mathematics teacher data, and the one to use for nonresponse in the school datafile is the school weight.
In general, careful modeling is required when using MICE to obtain valid statistical inferences (Marchenko, 2011). Another important point to remember concerns the order in which the imputation models should be imputed. Imputation using chained equations does not require us to specifically order the variables that must be imputed because the software imputes, by default, the variables from the most observed to the least observed.
In this paper, we also focused on the diagnostics of multiple imputation. The objective of this procedure is to identify those imputations that markedly differ from the observed values and then to pin down the cause of the problem. This process should determine if the imputation model should be remodeled or tested, for example, by means of sensitivity analyses, if there is a serious violation of the missingness assumptions. Also, because MICE is an iterative imputation method, its convergence needs to be evaluated.
Deciding on the number of imputations to conduct (especially if the number is likely to exceed the number theoretically considered sufficient—i.e., 5 to 10) is most easily done by computing FMI, the relative efficiency, or Monte Carlo errors (MCE). Studies show that computing MCE is a particularly suitable way of determining the number of imputations. When establishing the fraction of missingness, we can impute almost any fraction of missing data, provided that we do the imputation correctly and do not violate the assumption of MAR. However, if the fraction of missing data is large, say in the order of 30% to 50%, imputation methods must be applied with great caution (White et al., 2011).
In our illustrative analysis, we applied MICE to the student background data in the TIMSS 2007 datafile for Tunisia. We included all the variables used for imputation in the analysis model, and then performed five imputations, followed by another 30 imputations, after which we compared the results with the complete case analysis. The results showed that the estimates were relatively similar to those obtained from the complete case analysis. However, after imputation, the standard errors were smaller and the confidence intervals narrower.
Conclusion
In this paper, we reviewed two approaches to multiple imputation—the multivariate normal model and the chained equations approach. Multiple imputation is becoming easier and more tempting to use thanks to the existence of different software packages. It is receiving growing attention from researchers in various fields, some of whom consider it to be “thestateofthe art” missingdata technique (Schafer & Graham, 2002, p. 173) because it provides unbiased parameter estimates, does not reduce the variance of the variable in question, and preserves the entire dataset. The outcomes of our application of MICE to TIMSS data exhibiting nonresponse suggest that empirical research can be conducted effectively with whole datasets, thereby leading to more accurate conclusions about the information contained not only in the TIMSS databases but also in the databases of other largescale educational studies and surveys.
Endnotes
^{a} See Acock (2005) and Schafer and Graham (2002) for descriptions of each of these approaches and for a pointbypoint analysis of situations in which they are problematic.
^{b} Different software packages are available to implement the multiple imputation technique. See, for instance, Acock (2005), Horton and Kleinman (2007), and Mayer, Muche, and Hohl (2012).
^{c} http://www.ats.ucla.edu/stat/stata/seminars/missing_data/mi_in_stata_pt1.htm (IDRE, 2013a).
^{d} See STATA 12 documentation.
^{e} This program can be downloaded free of charge at http://sites.stat.psu.edu/~jls/misoftwa.html. NORM offers the user a number of normalizing transformations that can be implemented prior to the implementation phase and variables can be restored to their original metrics prior to analysis.
^{f} See also Van Buuren and Oudshoorn (2011) for a list of studies in which MICE has been used.
^{g} http://www.ats.ucla.edu/stat/stata/seminars/missing_data/mi_in_stata_pt2.htm (IDRE, 2013b).
^{h} This quantity figures prominently in multiple imputation. Also called the rate of missing information, it differs from the percentage of missing data. See Graham et al. (2007) and Schafer and Olsen (1998) for its formula and more discussion on it.
^{i} The UK700 data was a multicenter study conducted in four innercity areas. Participants were between the ages of 18 and 65, had a diagnosed psychotic illness, and experienced two or more psychiatric hospital admissions, the most recent within the previous two years. See White et al. (2011).
^{j} See the TIMSS website: timss.bc.edu.
^{k} Check whether the question is applicable or not to the country under study. If it is not applicable, then it cannot be considered as missing and should be removed from the analysis model.
^{l} Recently, Reiter and Si (2013) applied a different methodology (a fully Bayesian joint modeling approach) to impute missing background TIMSS 2007 data. They claim this approach offers advantages over MICE because it can capture complex dependencies and be applied effectively to nonresponse within largescale assessments.
^{m} It is also possible to test whether the MCAR assumption is plausible by using the multivariate test proposed by Little (1988).
^{n} Because testing the assumption of MAR against MNAR is impossible, it is always necessary to think about how the data being analyzed were collected (Marchenko & Eddings, 2011; Stuart et al., 2009).
^{o} It took roughly one hour to draw five multiple imputations.
^{p} The convergence of imputed continuous variables can be assessed using trace plots (see Marchenko, 2011).
^{q} Science results can be provided upon request from the authors.
^{r} See the Appendix to this paper.
^{s} We also referred to STATA 12 documentation when discussing the output.
^{t} It took us roughly six hours to draw 30 imputations.
Appendix
A) Rubin’s rules
After the creation of M imputed datasets, the M sets of parameter estimates and standard errors are combined into a single inference following rules established by Rubin (1987).
A significance test of the null hypothesis Q = 0 is performed by comparing the ratio $t=\frac{\overline{Q}}{S.E}$ to the same tdistribution.
B) the missing data pattern
C) Outputs
Output A.1
Output A.2
Output A.3
Output A.4
Output A.5
Output A.6
Output A.7
Declarations
Acknowledgement
We would like to acknowledge the helpful and constructive comments of the three anonymous reviewers of this paper.
Authors’ Affiliations
References
 Abayomi K, Gelman A, Levy M: Diagnostics for multivariate imputations. Applied Statistics 2008,57(Series C, Part 3):273–291.Google Scholar
 Acock AC: Working with missing data. Journal of Marriage and Family 2005,67(4):1012–1028. 10.1111/j.17413737.2005.00191.xView ArticleGoogle Scholar
 Allison PD: Multiple imputation for missing data: a cautionary tale. Sociological Methods and Research 2000, 28: 301–309. 10.1177/0049124100028003003View ArticleGoogle Scholar
 Allison PD: Missing data. Thousand Oaks, CA: Sage; 2002.Google Scholar
 Bodner TE: What improves with increased missing data imputations? Structural Equation Modeling 2008, 15: 651–675. 10.1080/10705510802339072View ArticleGoogle Scholar
 Carpenter J, Kenward M: Brief comments on computational issues with multiple imputation. 2008. Unpublished paper retrieved from http://missingdata.lshtm.ac.uk/downloads/mi_comp_issues.pdf Google Scholar
 Coleman JS, Campbell E, Hobson C, McPartland J, Mood A, Weinfield F, York R: Equality of educational opportunity. Washington, DC: US Government Printing Office; 1966.Google Scholar
 Collins LM, Schafer JL, Kam CM: A comparison of inclusive and restrictive strategies in modern missing data procedures. Psychological Methods 2001,6(4):330–351.View ArticleGoogle Scholar
 Dempster AP, Laird NM, Rubin DB: Maximum likelihood from incomplete data via the EM algorithm. Journal of the Royal Statistical Society: Series B: Methodological 1977,39(1):1–38.Google Scholar
 Enders C, Dietz S, Montague M, Dixon J: Modern alternatives for dealing with missing data in special education research. Advances in Learning and Behavioral Disabilities 2006, 19: 105–133.Google Scholar
 Foy P, Olson JF (Eds): TIMSS 2007 international database and user guide. Chestnut Hill, MA: Boston College; 2007.Google Scholar
 Graham JW: Missing data analysis: making it work in the real world. Annual Review of Psychology 2009, 60: 549–576. 10.1146/annurev.psych.58.110405.085530View ArticleGoogle Scholar
 Graham JW, Olchowski AE, Gilreath TD: How many imputations are really needed? Some practical clarifications of multiple imputation theory. Prevention Science 2007, 8: 206–213. 10.1007/s1112100700709View ArticleGoogle Scholar
 Horton NJ, Kleinman KP: Much ado about nothing: a comparison of missing data methods and software to fit incomplete data regression models. The American Statistician 2007,61(1):79–90. 10.1198/000313007X172556View ArticleGoogle Scholar
 Institute for Digital Research and Education (IDRE): Statistical computing seminars: multiple imputation in Stata, part 1. Los Angeles, CA: IDRE, University of California at Los Angeles; 2013a. Retrieved from http://www.ats.ucla.edu/stat/stata/seminars/missing_data/mi_in_stata_pt2.htm Google Scholar
 Institute for Digital Research and Education (IDRE): Statistical computing seminars: multiple imputation in Stata, part 2. Los Angeles, CA: IDRE, University of California at Los Angeles; 2013b. Retrieved from http://www.ats.ucla.edu/stat/stata/seminars/missing_data/mi_in_stata_pt2.htm Google Scholar
 Jolani S, Van Buuren S, Frank LE: Combining the completedata and nonresponse models for drawing imputations under MAR. Journal of Statistical Computation and Simulation 2011, 1: 1–12. doi:10.1080/00949655.2011.639773Google Scholar
 Lee KJ, Carlin JB: Multiple imputation for missing data: fully conditional specification versus multivariate normal imputation. American Journal of Epidemiology 2010,171(5):624–632. 10.1093/aje/kwp425View ArticleGoogle Scholar
 Little RJA: A test of missing completely at random for multivariate data with missing values. Journal of the American Statistical Association 1988,83(404):1198–1202. 10.1080/01621459.1988.10478722View ArticleGoogle Scholar
 Little RJA: Regression with missing X’s: a review. Journal of the American Statistical Association 1992,87(420):1227–1237.Google Scholar
 Little RJA, Rubin DB: Statistical analysis with missing data. Hoboken, NJ: Wiley; 2002.View ArticleGoogle Scholar
 Marchenko YV: Chained equations and more in multiple imputation in Stata. 2011. Paper presented at the 2011 Italian Stata Users Group Meeting. Retrieved from http://www.stata.com/meeting/italy11/abstracts/italy11_marchenko.pdf Google Scholar
 Marchenko YV, Eddings WD: A note on how to perform multipleimputation diagnostics in Stata. College Station, TX: StataCorp; 2011. Retrieved from http://www.stata.com/users/ymarchenko/midiagnote.pdf Google Scholar
 Mayer B, Muche R, Hohl K: Software for the handling and imputation of missing data: an overview. Clinical Trials 2012,2(1):1–8. Available online at http://www.omicsgroup.org/journals/JCTR/JCTR2–103.php?aid=3766 Google Scholar
 Meng XL: Multiple imputation inferences with uncongenial sources of input. Statistical Science 1994,9(4):538–558.Google Scholar
 Moons KG, Donders RA, Stijnen T, Harrell FE Jr: Using the outcome for imputation of missing predictor values was preferred. Journal of Clinical Epidemiology 2006, 59: 1092–1101. 10.1016/j.jclinepi.2006.01.009View ArticleGoogle Scholar
 Moulton BR: Random group effects and the precision of regression estimates. Journal of Econometrics 1986,32(3):385–397. 10.1016/03044076(86)900217View ArticleGoogle Scholar
 Nielsen SF: Proper and improper multiple imputation. International Statistical Review 2003,71(3):593–607.View ArticleGoogle Scholar
 Olson JF, Martin MO, Mullis IVS (Eds): TIMSS 2007 technical report. Chestnut Hill, MA: Boston College; 2007.Google Scholar
 Oudshoorn CGM, Van Buuren S, Rijckevorsel V: Flexible multiple imputation by chained equations of the AVO95 survey (TNO Report PG/VGZ/99.045). Leiden, the Netherlands: TNO Prevention and Health; 1999.Google Scholar
 Peugh JL, Enders CK: Missing data in educational research: a review of reporting practices and suggestions for improvement. Review of Educational Research 2004,74(4):525–556. 10.3102/00346543074004525View ArticleGoogle Scholar
 Raghunathan TE, Bondarenko I: Diagnostics for multiple imputations. 2007. Available on the Social Science Research Network website: http://papers.ssrn.com/sol3/papers.cfm?abstract_id=1031750 Google Scholar
 Raghunathan TE, Lepkowski JM, Van Hoewyk J, Solenberger P: A multivariate technique for multiply imputing missing values using a sequence of regression models. Survey Methodology 2001, 27: 85–95.Google Scholar
 Reiter JP, Si Y: Nonparametric Bayesian multiple imputation for incomplete categorical variables in largescale assessment surveys. 2013. Unpublished paper retrieved from ~jerry/Papers/jebs12.pdf http://www.stat.duke.edu/ Google Scholar
 Royston P, White IR: Multiple imputation by chained equations (MICE): implementation in Stata. Journal of Statistical Software 2011,45(4):1–20.Google Scholar
 Rubin DB: Inference and missing data. Biometrika 1976, 63: 581–592. 10.1093/biomet/63.3.581View ArticleGoogle Scholar
 Rubin DB: Formalizing subjective notions about the effect of nonrespondents in sample surveys. Journal of the American Statistical Association 1977, 72: 538–543. 10.1080/01621459.1977.10480610View ArticleGoogle Scholar
 Rubin DB: Multiple imputations in sample surveysa phenomenological Bayesian approach to nonrepsonse. Proceedings of the Survey Research Methods Section of the American Statistical Association 1978, 20–34.Google Scholar
 Rubin DB: Multiple imputation for nonresponse in surveys. New York, NY: John Wiley; 1987.View ArticleGoogle Scholar
 Rubin DB: Multiple imputation after 18+ years. Journal of the American Statistical Association 1996, 91: 473–489. 10.1080/01621459.1996.10476908View ArticleGoogle Scholar
 Rutkowski L, Gonzalez E, Joncas M, Von Davier M: International largescale assessment data: Issues in secondary analysis and reporting. Educational Researcher 2010,39(2):142–151. 10.3102/0013189X10363170View ArticleGoogle Scholar
 Schafer JL: Analysis of incomplete multivariate data. New York, NY: Chapman and Hall; 1997.View ArticleGoogle Scholar
 Schafer JL: Multiple imputation: a primer. Statistical Methods in Medical Research 1999, 8: 3–15. 10.1191/096228099671525676View ArticleGoogle Scholar
 Schafer JL: NORM: Multiple imputation of incomplete multivariate data under a normal model [computer software]. University Park, PA: Department of Statistics, Pennsylvania State University; 1999.Google Scholar
 Schafer JL: Analyzing the NHANES III multiply imputed data set: methods and examples prepared for the national center for health statistics. Hyattsville, MD: National Center for Health Statistics; 2001.Google Scholar
 Schafer JL: Multiple imputation in multivariate problems when the imputation and analysis models differ. Statistica Neerlandica 2003,57(1):19–35. 10.1111/14679574.00218View ArticleGoogle Scholar
 Schafer JL, Graham JW: Missing data: our view of the state of the art. Psychological Methods 2002,7(2):147–177.View ArticleGoogle Scholar
 Schafer JL, Olsen MK: Multiple imputation for multivariate missing data problems: a data analyst’s perspective. Multivariate Behavioral Research 1998, 33: 545–571. 10.1207/s15327906mbr3304_5View ArticleGoogle Scholar
 Sterne JAC, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, Wood AM, Carpenter JR: Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. British Medical Journal 2009, 339: 157–160.Google Scholar
 Stuart EA, Azur M, Frangakis C, Leaf P: Multiple imputation with large data sets: a case study of the children’s mental health initiative. American Journal of Epidemiology 2009,169(9):1133–1139. 10.1093/aje/kwp026View ArticleGoogle Scholar
 Su YS, Gelman A, Hill J, Yajima M: Multiple imputation with diagnostics (mi) in R: opening windows into the black box. Journal of Statistical Software 2011,45(2):1–13.Google Scholar
 Taylor JMG, Cooper KL, Wei JT, Sarma RV, Raghunathan TE, Heeringa SG: Use of multiple imputation to correct for nonresponse bias in a survey of urologic symptoms among AfricanAmerican men. American Journal of Epidemiology 2002, 156: 774–782. 10.1093/aje/kwf110View ArticleGoogle Scholar
 Van Buuren S: Multiple imputation of discrete and continuous data by fully conditional specification. Statistical Methods in Medical Research 2007,16(3):219–242. 10.1177/0962280206074463View ArticleGoogle Scholar
 Van Buuren S, Oudshoorn KG: Mice: Multivariate imputation by chained equations in R. Journal of Statistical Software 2011,45(3):1–67.Google Scholar
 Van Buuren S, Boshuizen HC, Knook DL: Multiple imputation of missing blood pressure covariates in survival analysis. Statistics in Medicine 1999, 18: 681–694. 10.1002/(SICI)10970258(19990330)18:6<681::AIDSIM71>3.0.CO;2RView ArticleGoogle Scholar
 Van Buuren S, Brand JPL, GroothuisOudshoorn CGM, Rubin DB: Fully conditional specification in multivariate imputation. Journal of Statistical Computation and Simulation 2006, 76: 1049–1064. 10.1080/10629360600810434View ArticleGoogle Scholar
 White IR, Daniel R, Royston P: Avoiding bias due to perfect prediction in multiple imputation of incomplete categorical variables. Computational Statistics and Data Analysis 2010, 54: 2267–2275. 10.1016/j.csda.2010.04.005View ArticleGoogle Scholar
 White IR, Royston P, Wood AM: Multiple imputation using chained equations: Issues and guidance for practice. Statistics in Medicine 2011, 30: 377–399. 10.1002/sim.4067View ArticleGoogle Scholar
 Zhang P: Multiple imputation: theory and method. International Statistical Review 2003,71(3):581–592.View ArticleGoogle Scholar
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.